I started Progesterone about a year into HRT and was on it for over a year without seeing much of any effect. Then I tried something that I saw mentioned as an alternate means of delivery; Instead of taking orally, take by rectal insertion,. Within a few months my boobs went from Bs to Ds, not bad considering my Mom was a C,. One possible warning however is that it can apparently also play with your sexuality; it turned me, Straight(hot for guys) and even made me a bit "baby crazy" wanting to get pregnant,,. Luckily I dont have to worry about that at least :) . I take it in the morning after my BM. Just use a tiny bit of KY, to help slide it in,,. Taking this way, main lines it into your bloodstream, where orally, most of it gets eaten up in your digestive tract.