Hi, from another "later in life" Transitioner. How are you doing lately w/ your Estrogen if I may ask? I initially started using patches, but soon after moved up to injections, weekly. How are you doing your injections' Intramuscular or SubQuteral(sp)? What size needle are you using? I had been using 22ga, and those hurt, and I often bled. Plus there would sometimes be a bit of soreness at the injection site for a few days after. I recently changed to smaller 25ga needles which are much easier, and Im now doing "SubQ" injections in my abdomen, which is far less painful than in my upper thigh. Good luck :)